Article
Negative Selection of T Cells by Helicobacter pylori as a Model for Bacterial Strain Selection by Immune Evasion
1 Jul 2001
Abstract excerpt
The majority of humans infected with Helicobacter pylori maintain a lifelong infection with strains bearing the cag pathogenicity island (PAI). H. pylori inhibits T cell responses and evades immunity so the mechanism by which infection impairs responsiveness was investigated. H. pylori caused apoptotic T cell death, whereas Campylobacter jejuni did not. The induction of apoptosis by H. pylori was blocked by an...
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