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Article

Helicobacter pylori inhibits the cleavage of TRAF1 via a CagA-dependent mechanism.

World journal of gastroenterology - 28 Dec 2016

Wan Xiu-Kun, Yuan Sheng-Ling, Wang Yan-Chun, Tao Hao-Xia, Jiang Wei, Guan Zhang-Yan, Cao Cheng, Liu Chun-Jie

Abstract excerpt

AIM: To study the impact on cleavage of tumor necrosis factor receptor-associated factor 1 (TRAF1) regulated by Helicobacter pylori (H. pylori). METHODS: Cleavage of TRAF1 was detected by western blotting in the human gastric cancer cell line AGS following treatment with an apoptosis inducer. Cleavage of TRAF1 mediated by caspase was examined in vitro using specific caspase inhibitors. The effect of the...

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Identifiers

PMID: 28082808
DOI: 10.3748/wjg.v22.i48.10566
PMCID: PMC5192267

Genes

TRAF1

Provenance

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