Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover.

Molecular microbiology - 1 Apr 2008

Pimkin Maxim, Markham George D

Abstract excerpt

Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyses the rate-limiting step in guanine nucleotide biosynthesis. IMPDH has an evolutionary conserved CBS subdomain of unknown function. The subdomain can be deleted without impairing the in vitro IMPDH catalytic activity and is the site for mutat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Carbon Radioisotopes
Share to Guanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine Triphosphate

Share to IMP Dehydrogenase

Share to Phosphorus Radioisotopes

Share to Sequence Deletion

Share to Streptococcus pyogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 18312263
DOI: 10.1111/j.1365-2958.2008.06153.x
PMCID: PMC2279236

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18312263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover.PMID 18312263Read ↗

A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis.Semantic proximity Read ↗

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.Semantic proximity Read ↗

A functional analysis of the allosteric nucleotide monophosphate binding site of carbamoyl phosphate synthetase.Semantic proximity Read ↗

IMPDH dysregulation in disease: a mini review.Semantic proximity Read ↗

Expression, Purification, and Characterization of Inosine 5′-Monophosphate Dehydrogenase from Borrelia burgdorferiSemantic proximity Read ↗

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.Semantic proximity Read ↗

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosaSemantic proximity Read ↗

IMP dehydrogenase-linked retinitis pigmentosa.Semantic proximity Read ↗

Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae.Semantic proximity Read ↗

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine.Semantic proximity Read ↗

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions.Semantic proximity Read ↗

Rationally-Stabilized Inhibited State of IMPDH Proposes a Novel Targeting Approach Involving Its Cross-Domain and Assembly Suppression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.