Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture.

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Article

Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 2001

Airey D C, Lu L, Williams R W

Abstract excerpt

To discover genes influencing cerebellum development, we conducted a complex trait analysis of variation in the size of the adult mouse cerebellum. We analyzed two sets of recombinant inbred BXD strains and an F2 intercross of the common inbred strains, C57BL/6J and DBA/2J. We measured cerebellar size as the weight or volume of fixed or histologically processed tissue. Among BXD recombinant inbred strains, the...

Topics

Animals
Body Weight
Brain
Cerebellum
Chromosome Mapping
Chromosomes
Crosses, Genetic
Female
Genotype
Lod Score
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Inbred DBA

Mice, Inbred Strains

Organ Size

Quantitative Trait, Heritable

Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 11438585
PMCID: PMC6762866

Genes

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