Article
Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects.
Genes, brain, and behavior - 1 Aug 2003
Peirce J L, Chesler E J, Williams R W, Lu L
Abstract excerpt
We recently mapped two quantitative trait loci that have widespread effects on hippocampal architecture in mouse: Hipp1a and Hipp5a. We also noted remarkable strain differences in the relative sizes of different hippocampal regions. Estimated heritable variation for these differences was 42% in hippocampus proper, 40% in dentate gyrus, 31% in granule cell layer and 18% in pyramidal cell layer. Region size varied...
Topics
- Age Factors
- Animals
- Body Weight
- Cell Count
- Chromosome Mapping
- Crosses, Genetic
- Dentate Gyrus
- Female
- Gene Expression
- Genetic Variation
- Genotype
- Hippocampus
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Inbred Strains
- Organ Size