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Article

Varying responses of PML-RARA with different genetic mutations to arsenic trioxide

5 Nov 2015

Abstract excerpt

Resistance to arsenic and/or all-trans retinoic acid (ATRA) is a challenging problem in the clinical management of acute promyelocytic leukemia (APL). Acquired genetic mutations in the PML moiety of the PML-RARA fusion gene are found in some patients with relapsed/refractory APL. Whether all of the identified point mutations play a role and have a similar function in the mechanisms of arsenic resistance remains...

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Identifiers

PMID: 26537301
DOI: 10.1182/blood-2015-04-637678

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