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Article

An immune-responsive Serpin regulates the melanization cascade in Drosophila.

Developmental cell - 1 Oct 2002

De Gregorio Ennio, Han Sung-Jun, Lee Won-Jae, Baek Min-Ji, Osaki Tsukasa, Kawabata Shun-Ichiro, Lee Bok-Leul, Iwanaga Sadaaki, Lemaitre Bruno, Brey Paul T

Abstract excerpt

In arthropods, the melanization reaction is associated with multiple host defense mechanisms leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a...

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PMID: 12408809
DOI: 10.1016/s1534-5807(02)00267-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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