Article
Hemolytic and antimicrobial activities of the twenty-four individual omission analogues of melittin.
Biochemistry - 14 May 1991
Blondelle S E, Houghten R A
Abstract excerpt
Although melittin's hemolytic activity has been extensively studied, the orientation of membrane-bound melittin remains uncertain. We have investigated the effect of individually omitted amino acid residues on melittin's activity and related these results to the existing models of melittin-membrane interaction. The extent of hemolysis of the omission analogues closely followed the four known conformational...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Chromatography, High Pressure Liquid
- Hemolysis
- Melitten
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Pseudomonas aeruginosa
- Staphylococcus aureus