Article

Engineering a wolf spider A-family toxin towards increased antimicrobial activity but low toxicity

2024-03-06

Abstract excerpt

Peptides with insecticidal, antimicrobial and/or cytolytic activities, also known as spider venom antimicrobial peptides (AMPs), can be found in the venoms of RTA-clade spiders. They show translational potential as therapeutic leads. A set of 52 AMPs has been described in the Chinese wolf spider ( Lycosa shansia ), and many have been shown to exhibit antibacterial effects. Here we explored the potential to enhanc...

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Literature Corpus work: 250da4d1-949a-50e9-be35-adecfe3cc49e
DOI: 10.1101/2024.03.04.583312

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