Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.

Genomics - 10 Apr 1995

Stanier P, Henson J N, Eddleston J, Moore G E, Copp A J

Abstract excerpt

A genetic basis for neural tube defects (NTD) is rarely doubted, but the genes involved have not yet been identified. This is partly due to a lack of suitable families on which to perform linkage analysis. An alternative approach is to use the many mouse genes that cause NTD as a means of isolating their human homologues. Loop-tail (Lp) is a semidominant mouse gene that, in homozygous mutants, causes the severe...

Topics

Animals
Chromosome Mapping
Chromosomes, Human, Pair 1
Crosses, Genetic
Female
Genetic Linkage
Genetic Markers
Humans
Male
Mice
Mice, Inbred CBA
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neural Tube Defects

Source

Identifiers

PMID: 7607670
DOI: 10.1016/0888-7543(95)80165-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7607670-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.PMID 7607670Read ↗

Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).Semantic proximity Read ↗

Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.Semantic proximity Read ↗

Identification of the mouse Loop-tail gene: a model for human craniorachischisis?Semantic proximity Read ↗

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.Semantic proximity Read ↗

Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1.Semantic proximity Read ↗

Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation.Semantic proximity Read ↗

Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.Semantic proximity Read ↗

Genetic mapping of meander tail, a mouse mutation affecting cerebellar development.Semantic proximity Read ↗

Genetic landmarks for defects in mouse neural tube closure.Semantic proximity Read ↗

Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.Semantic proximity Read ↗

Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping.Semantic proximity Read ↗

The clf1 gene maps to a 2- to 3-cM region of distal mouse chromosome 11.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.