Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation.

doi:10.1371/journal.ppat.1006131

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Article

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation.

PLoS pathogens - 1 Jan 2017

Day Alison M, Smith Deborah A, Ikeh Mélanie A C, Haider Mohammed, Herrero-de-Dios Carmen M, Brown Alistair J P, Morgan Brian A, Erwig Lars P, MacCallum Donna M, Quinn Janet

Abstract excerpt

The Ypd1 phosphorelay protein is a central constituent of fungal two-component signal transduction pathways. Inhibition of Ypd1 in Saccharomyces cerevisiae and Cryptococcus neoformans is lethal due to the sustained activation of the 'p38-related' Hog1 stress-activated protein kinase (SAPK). As tw...

Topics

Animals
Candida albicans
Down-Regulation
Female
Fungal Proteins
Gene Deletion
Gene Expression Regulation, Fungal
Humans
MAP Kinase Signaling System
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinases

Models, Biological

Phenotype

Phosphorylation

Stress, Physiological

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 28135328
DOI: 10.1371/journal.ppat.1006131
PMCID: PMC5300278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28135328-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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