Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.

Leukemia research - 1 Feb 2010

Yokohama Akihiko, Mishra Anjali, Mitsui Takeki, Becknell Brian, Johns Jessica, Curphey Douglas, Blaser Bradley W, Vandeusen Jeffrey B, Mao Hsiaoyin, Yu Jianhua, Caligiuri Michael A

Abstract excerpt

Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blast Crisis
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-15

Share to Killer Cells, Natural

Share to Leukemia, Large Granular Lymphocytic

Share to T-Lymphocytes

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 19660811
DOI: 10.1016/j.leukres.2009.06.031
PMCID: PMC2814907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.PMID 19660811Read ↗

Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.Semantic proximity Read ↗

NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and humanSemantic proximity Read ↗

A modern view of LGL leukemia.Semantic proximity Read ↗

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia.Semantic proximity Read ↗

Animal models for chronic lymphocytic leukemiaSemantic proximity Read ↗

The TCL1 mouse as a model for chronic lymphocytic leukemia.Semantic proximity Read ↗

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory SequencesSemantic proximity Read ↗

Humanized mouse model supports development, function, and tissue residency of human natural killer cellsSemantic proximity Read ↗

A lineage-specific <i>STAT5B</i> <sup>N642H</sup> mouse model to study NK-cell leukemiaSemantic proximity Read ↗

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation.Semantic proximity Read ↗

Large granular lymphocyte leukemia.Semantic proximity Read ↗

T-cell and natural killer-cell large granular lymphocyte leukemia neoplasiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.