Article
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.
Leukemia research - 1 Feb 2010
Yokohama Akihiko, Mishra Anjali, Mitsui Takeki, Becknell Brian, Johns Jessica, Curphey Douglas, Blaser Bradley W, Vandeusen Jeffrey B, Mao Hsiaoyin, Yu Jianhua, Caligiuri Michael A
Abstract excerpt
Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive...
Topics
- Animals
- Blast Crisis
- Cell Proliferation
- Chromosomes, Mammalian
- Disease Models, Animal
- Interferon-gamma
- Interleukin-15
- Killer Cells, Natural
- Leukemia, Large Granular Lymphocytic
- Mice
- Mice, Transgenic
- Phenotype
- T-Lymphocytes