Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice.

European journal of cancer (Oxford, England : 1990) - 1 Feb 2011

Fedele Monica, Visone Rosa, De Martino Ivana, Palmieri Dario, Valentino Teresa, Esposito Francesco, Klein-Szanto Andres, Arra Claudio, Ciarmiello Andrea, Croce Carlo M, Fusco Alfredo

Abstract excerpt

HMGA1 gene rearrangements have been frequently described in human lipomas. In vitro studies suggest that HMGA1 proteins have a negative role in the control of adipocyte cell growth, and that HMGA1 gene truncation acts in a dominant-negative fashion. Therefore, to define better the role of the HMGA1 alterations in the generation of human lipomas, we generated mice carrying an Hmga1b truncated (Hmga1b/T) gene....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to E2F1 Transcription Factor

Share to Gigantism

Share to Lipomatosis

Share to Lymphoma, B-Cell

Share to Mice, Transgenic

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 21044834
DOI: 10.1016/j.ejca.2010.09.045

Genes

HMGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice.PMID 21044834Read ↗

A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas.Semantic proximity Read ↗

Role of the high mobility group A proteins in human lipomasSemantic proximity Read ↗

Misexpression of Full-length HMGA2 Induces Benign Mesenchymal Tumors in MiceSemantic proximity Read ↗

Clinical and Molecular Investigation of Familial Multiple Lipomatosis: Variants in the HMGA2 GeneSemantic proximity Read ↗

Lipoid Proteinosis Resulting from a Large Homozygous Deletion Affecting Part of the ECM1 Gene and Adjacent Long Non-coding RNA.Semantic proximity Read ↗

Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.Semantic proximity Read ↗

Early B-cell transcription factor-2 defect as a novel cause of lipodystrophy: disruption of the adipose tissue character and integritySemantic proximity Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissueSemantic proximity Read ↗

LIPE-related lipodystrophic syndrome: clinical features and disease modeling using adipose stem cells.Semantic proximity Read ↗

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptorSemantic proximity Read ↗

HMGA2 is expressed in an allele-specific manner in human lipomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.