Article
Analysis of apoptosis induced by HIV-1 Vpr and examination of the possible role of the hHR23A protein.
Experimental cell research - 15 Jul 2001
Gaynor E M, Chen I S
Abstract excerpt
The HIV-1 Vpr protein induces apoptosis of cells, the mechanism of which is unknown. To clarify how this function may be related to other Vpr functions, we simultaneously assessed the effects of multiple point mutations upon various Vpr properties. Our data suggest that induction of arrest by Vpr may be unnecessary for induction of apoptosis. This is exemplified by a C-terminal mutant, R80A, that does not arrest...
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