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Article

Dual role of the HIV-1 vpr protein in the modulation of the apoptotic response of T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2000

Conti L, Matarrese P, Varano B, Gauzzi M C, Sato A, Malorni W, Belardelli F, Gessani S

Abstract excerpt

We investigated the effect of vpr, physiologically expressed during the course of an acute HIV-1 infection, on the response of infected cells to apoptotic stimuli as well as on the HIV-induced apoptosis. At 48 h after infection, Jurkat cells exhibited a lower susceptibility to undergo apoptosis with respect to uninfected cells. This effect was not observed following infection with either a vpr-mutated virus or a...

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Source

Identifiers

PMID: 10975846
DOI: 10.4049/jimmunol.165.6.3293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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