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Article

HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.

PLoS pathogens - 1 Dec 2006

Andersen Joshua L, DeHart Jason L, Zimmerman Erik S, Ardon Orly, Kim Baek, Jacquot Guillaume, Benichou Serge, Planelles Vicente

Abstract excerpt

The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage-signaling protein ATR as the cellular factor that mediates Vpr-induced G2 arrest and apoptosis. Here, we examine the mechanism of induction of apoptosis by Vpr and how it relates to induction of G2 arrest. We find that entry into G2 is a requirement for Vpr to induce...

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Identifiers

PMID: 17140287
DOI: 10.1371/journal.ppat.0020127
PMCID: PMC1665652

Genes

ATR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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