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Mutational Analysis of Vpr-Induced G 2 Arrest, Nuclear Localization, and Cell Death in Fission Yeast

1 Apr 1999

Abstract excerpt

Cell cycle G2 arrest, nuclear localization, and cell death induced by human immunodeficiency virus type 1 Vpr were examined in fission yeast by using a panel of Vpr mutations that have been studied previously in human cells. The effects of the mutations on Vpr functions were highly similar between fission yeast and human cells. Consistent with mammalian cell studies, induction of cell cycle G2 arrest by Vpr was...

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PMID: 10074177
DOI: 10.1128/jvi.73.4.3236-3245.1999

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