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Article

Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia.

Lancet (London, England) - 16 Jun 2001

Premawardhena A, Fisher C A, Fathiu F, de Silva S, Perera W, Peto T E, Olivieri N F, Weatherall D J

Abstract excerpt

Chronic hyperbilirubinaemia, gallstone formation, and gall bladder disease are unusually common in people with haemoglobin E beta thalassaemia in Sri Lanka. To determine whether this has a genetic basis we compared the bilirubin levels and frequency of gallstones in patients with different alleles of the UGT*1 gene. There was a significantly higher bilirubin level in those with the 7/7 genotypes compared with 6/6...

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Identifiers

PMID: 11425418
DOI: 10.1016/s0140-6736(00)05082-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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