Article
Effect of mutagen-induced cell lethality on the dose response of germline mutations.
Environmental and molecular mutagenesis - 1 Jan 2001
Lee W R, Perantie D C, Clark K B, Guillot D A, Wilson V L
Abstract excerpt
Molecular tests for mutations require a sample of tissue from which DNA is extracted, to determine the presence or absence of one or more mutations per sample. To ensure mutation fixation each sample must consist of an equal number of cells that have had one or more DNA replications. In an in vivo test, surviving stem cells compensate to give the same number of cells per sample, leaving as the only evidence for...
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