Article

Rapid Intracellular Delivery of Human Heat Shock Protein 72 Inhibits Neurodegeneration and Oxidative Damage After a Traumatic Brain Injury

2026-05-07

Abstract excerpt

Fv-HSP72 is a rapid cell-penetrating human heat shock protein for the treatment of traumatic organ injuries. We have shown this re-engineered protein (HSP72) is capable of crossing the blood brain barrier (BBB) of rats suffering a controlled cortical impact (CCI) and remains in brain tissue for up to 12 hours; long after clearance from the cortex of uninjured rats. Peptide sequences unique to Fv-HSP72 allow for it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83fa15fa-9018-586c-ad0f-7db8c3020c7e
DOI: 10.64898/2026.05.03.722564

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid Intracellular Delivery of Human Heat Shock Protein 72 Inhibits Neurodegeneration and Oxidative Damage After a Traumatic Brain InjuryDOI 10.64898/2026.05.03.722564Read

Rapid Intracellular Delivery of Human Heat Shock Protein 72 Prevents Memory Loss and Inhibits Neurodegeneration up to 9 Days After a Blast InjurySemantic proximity Read

Heat shock proteins: multiple neuroprotective functions and implications for neurologic disease.Semantic proximity Read

The induction of heat shock proteins as a potential strategy to treat neurodegenerative disordersSemantic proximity Read

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and NeuroprotectionSemantic proximity Read

Novel Therapeutic Strategy Targeting Hspa8 for Ischemic Brain InjurySemantic proximity Read

Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human NeuronsSemantic proximity Read

Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injurySemantic proximity Read

Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition.Semantic proximity Read

Whole genome transcriptomic reveals heat stroke molecular signatures in humansSemantic proximity Read

A Novel Model of Traumatic Brain Injury in Adult Zebrafish Demonstrates Response to Injury and Treatment Comparable with Mammalian ModelsSemantic proximity Read

Attenuation of Reactive Astrogliosis Accompanies Neurological Recovery Induced by Novel Poly-Target 2,3-Benzodiazepines After Experimental Traumatic Brain InjurySemantic proximity Read

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.Semantic proximity Read