Article
Bidirectional activity and orientation-dependent specificity of the rat aldolase C promoter in transgenic mice.
FEBS letters - 15 Jun 2001
Phan Dinh Tuy F, Porteu A, Kahn A, Skala H
Abstract excerpt
We previously reported that the rat aldolase C 115 bp promoter is sufficient to ensure the brain specific expression of the chloramphenicol acetyltransferase reporter gene in transgenic mice. We identify in a further reduced 84 bp promoter several putative binding sites for the transcriptional factors Sp1, USF, AP1, and AP2. Deletion or mutation of these partially overlapping binding sites results in inactivation...
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