Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles.

doi:10.1073/pnas.92.26.12115

Article

Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 1995

Bowman B H, Jansen L, Yang F, Adrian G S, Zhao M, Atherton S S, Buchanan J M, Greene R, Walter C, Herbert D C, Weaker F J, Chiodo L K, Kagan-Hallet K, Hixson J E

Abstract excerpt

Transgenic mice carrying heterologous genes directed by a 670-bp segment of the regulatory sequence from the human transferrin (TF) gene demonstrated high expression in brain. Mice carrying the chimeric 0.67kbTF-CAT gene expressed TF-CAT in neurons and glial cells of the nucleus basalis, the cere...

Topics

Alleles
Animals
Apolipoproteins E
Base Composition
Base Sequence
Brain
Chloramphenicol O-Acetyltransferase
Cloning, Molecular
DNA Primers
Gene Expression

Humans

In Situ Hybridization

Liver

Mice

Mice, Transgenic

Molecular Sequence Data

Neuroglia

Neurons

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