Article
Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice.
Experimental and molecular pathology - 1 Jun 2001
Zhang S S, Welte T, Fu X Y
Abstract excerpt
Stat4 (signal transducer and activator of transcription) can be activated by specific cytokines, such as IL-12, IFN-alpha, and IL-2. Since IL-12 has been implicated in tumor surveillance and cancer treatment, we hypothesized that its signaling mediator, Stat4, may repress tumor growth. Mice lacking Stat4 allowed us to directly assess the role of Stat4 in tumor surveillance. Lymphomas were chemically induced by...
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