Article
Electroconvulsive thresholds of inbred mouse strains.
Genomics - 15 Jun 2001
Frankel W N, Taylor L, Beyer B, Tempel B L, White H S
Abstract excerpt
The electroconvulsive threshold (ECT) test is used commonly in the screening of anti-epileptic drugs in rodent models, but little is known about its genetic or mechanistic basis. Thresholds for minimal clonic, maximal tonic, or psychomotor (partial) seizures were determined in 16 different inbred mouse strains in two different laboratories. A wide range of thresholds was observed, suggesting that a variety of...
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