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Article

Malignant hyperthermia: an inherited disorder of skeletal muscle Ca+ regulation.

Bioscience reports - 1 Apr 2001

Louis C F, Balog E M, Fruen B R

Abstract excerpt

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle characterized by muscle contracture and life-threatening hypermetabolic crisis following exposure to halogenated anesthetics and depolarizing muscle relaxants during surgery. Susceptibility to MH results from mutations in Ca2+ channel proteins that mediate excitation-contraction (EC) coupling, with the ryanodine receptor Ca2+ release...

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PMID: 11725864
DOI: 10.1023/a:1013644107519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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