Article
High-resolution multipoint linkage-disequilibrium mapping in the context of a human genome sequence.
American journal of human genetics - 1 Jul 2001
Rannala B, Reeve J P
Abstract excerpt
A new method is presented for fine-scale linkage disequilibrium (LD) mapping of a disease mutation; it uses multiple linked single-nucleotide polymorphisms, restriction-fragment-length polymorphisms, or microsatellite markers and incorporates information from an annotated human genome sequence (HGS) and from a human mutation database. The method takes account of population demographic effects, using Markov chain...
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