Article
Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland.
Nature genetics - 1 Nov 1992
Hästbacka J, de la Chapelle A, Kaitila I, Sistonen P, Weaver A, Lander E
Abstract excerpt
Linkage disequilibrium mapping in isolated populations provides a powerful tool for fine structure localization of disease genes. Here, Luria and Delbrück's classical methods for analysing bacterial cultures are adapted to the study of human isolated founder populations in order to estimate (i) t...
Topics
- Base Sequence
- Child
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Female
- Finland
- Genetic Markers
- Genetics, Population
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Osteochondrodysplasias
- Pedigree
- Polymorphism, Genetic