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Article

Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland.

Nature genetics - 1 Nov 1992

Hästbacka J, de la Chapelle A, Kaitila I, Sistonen P, Weaver A, Lander E

Abstract excerpt

Linkage disequilibrium mapping in isolated populations provides a powerful tool for fine structure localization of disease genes. Here, Luria and Delbrück's classical methods for analysing bacterial cultures are adapted to the study of human isolated founder populations in order to estimate (i) the recombination fraction between a disease locus and a marker; (ii) the expected degree of allelic homogeneity in a...

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PMID: 1345170
DOI: 10.1038/ng1192-204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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