Article
Polymorphism of tumor necrosis factor-beta and alcohol dehydrogenase genes and alcoholic brain atrophy in Japanese patients.
Alcoholism, clinical and experimental research - 1 Jun 2001
Yamauchi M, Takamatsu M, Maezawa Y, Takagi M, Araki T, Satoh S, Toda And G, Saito S
Abstract excerpt
BACKGROUND: Alcohol abuse can induce brain atrophy, but it only occurs in some alcoholics. Many inflammatory cytokines such as tumor necrosis factor (TNF) are produced rapidly in the brain by experimental or clinical injury. METHOD: To investigate whether genetic polymorphism of TNF was related to alcoholic brain atrophy, we determined restriction fragment-length polymorphisms of the TNF-beta genes in 72 male...
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