Article
Single nucleotide polymorphisms and microsatellite alleles of tumor necrosis factor alpha and interleukin-10 genes and the risk of advanced chronic alcoholic liver disease.
Liver - 1 Jun 2002
Ladero José M, Fernández-Arquero Miguel, Tudela José I, Agúndez José A G, Díaz-Rubio Manuel, Benítez Julio, de la Concha Emilio G
Abstract excerpt
BACKGROUND: Only a minority of ethanol abusers develop advanced chronic alcoholic liver disease (CALD). In CALD there is a imbalance between TNF alpha and IL-10, which may be modulated by several polymorphisms at both genetic loci. Our aim has been to elucidate the possible relation between these polymorphisms and the risk of CALD. PATIENTS AND METHODS: 147 patients with advanced CALD and 355 healthy controls...
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