Article
Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.
Cancer research - 1 Aug 2004
Gaitanos Thomas N, Buey Rubén M, Díaz J Fernando, Northcote Peter T, Teesdale-Spittle Paul, Andreu José M, Miller John H
Abstract excerpt
Peloruside A (peloruside), a microtubule-stabilizing agent from a marine sponge, is less susceptible than paclitaxel to multidrug resistance arising from overexpression of the P-glycoprotein efflux pump and is not affected by mutations that affect the taxoid binding site of beta-tubulin. In vitro studies with purified tubulin indicate that peloruside directly induces tubulin polymerization in the absence of...
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