Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype.

Journal of cellular biochemistry - 1 Dec 2003

Faccio Roberta, Zou Wei, Colaianni Graziana, Teitelbaum Steven L, Ross F Patrick

Abstract excerpt

Osteoclasts are macrophage derived cells and as such are subject to regulation by molecules impacting other members of the immune system. Dap12 is an adaptor protein expressed by NK cells and B and T lymphocytes. Dap12 also mediates maturation of myeloid cells and is expressed by osteoclasts which are dysfunctional in its absence. We find Dap12-/- osteoclast precursors fail to differentiate, in vitro, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcitonin
Share to Cathepsin K
Share to Cathepsins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Precursors

Share to Macrophage Colony-Stimulating Factor

Share to RANK Ligand

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Syk Kinase

Source

Identifiers

PMID: 14624447
DOI: 10.1002/jcb.10694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype.PMID 14624447Read ↗

Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent StateSemantic proximity Read ↗

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.Semantic proximity Read ↗

Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts.Semantic proximity Read ↗

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.Semantic proximity Read ↗

Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis.Semantic proximity Read ↗

Human circulating monocytes can express receptor activator of nuclear factor-kappaB ligand and differentiate into functional osteoclasts without exogenous stimulation.Semantic proximity Read ↗

Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes.Semantic proximity Read ↗

Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast ProgenitorsSemantic proximity Read ↗

Macrophage colony-stimulating factor and receptor activator NF-kappaB ligand fail to rescue osteoclast-poor human malignant infantile osteopetrosis in vitro.Semantic proximity Read ↗

Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice.Semantic proximity Read ↗

Effect of CD44 deficiency on in vitro and in vivo osteoclast formationSemantic proximity Read ↗

Osteotropic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.