Article
Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2001
Grifman M, Trepel M, Speece P, Gilbert L B, Arap W, Pasqualini R, Weitzman M D
Abstract excerpt
The human parvovirus adeno-associated virus type 2 (AAV-2) possesses many features that make it an attractive vector for gene delivery in vivo. However, its broad host range may limit its usefulness and effectivity in several gene therapy applications in which transgene expression needs to be limited to a specific organ or cell type. In this study, we explored the possibility of directing recombinant AAV-2...
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