Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors.

Gene therapy - 1 Aug 2012

Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus H A, Kleinschmidt J A, Müller O J

Abstract excerpt

We have demonstrated the potential of random peptide libraries displayed on adeno-associated virus (AAV)2 to select for AAV2 vectors with improved efficiency for cell type-directed gene transfer. AAV9, however, may have advantages over AAV2 because of a lower prevalence of neutralizing antibodies in humans and more efficient gene transfer in vivo. Here we provide evidence that random peptide libraries can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Dependovirus
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Gene Transfer Techniques

Share to Peptide Library

Share to Transduction, Genetic

Share to Umbilical Veins

Source

Identifiers

PMID: 21956692
DOI: 10.1038/gt.2011.143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors.PMID 21956692Read ↗

Development and Validation of Novel AAV2 Random Libraries Displaying Peptides of Diverse Lengths and at Diverse Capsid PositionsSemantic proximity Read ↗

Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells.Semantic proximity Read ↗

Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspectiveSemantic proximity Read ↗

AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytesSemantic proximity Read ↗

A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selectionSemantic proximity Read ↗

In vitro selection of viral vectors with modified tropism: the adeno-associated virus display.Semantic proximity Read ↗

Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids.Semantic proximity Read ↗

Non-integrating direct reprogramming generates therapeutic endothelial cells with sustained vascular regeneration capacity enhanced by nanomatrix deliverySemantic proximity Read ↗

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated VirusesSemantic proximity Read ↗

Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencingSemantic proximity Read ↗

Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries.Semantic proximity Read ↗

Ablating Adenovirus Type 5 Fiber–CAR Binding and HI Loop Insertion of the SIGYPLP Peptide Generate an Endothelial Cell-Selective AdenovirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.