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Article

Functional analysis of the putative integrin recognition motif on adeno-associated virus 9.

The Journal of biological chemistry - 16 Jan 2015

Shen Shen, Berry Garrett E, Castellanos Rivera Ruth M, Cheung Roland Y, Troupes Andrew N, Brown Sarah M, Kafri Tal, Asokan Aravind

Abstract excerpt

Adeno-associated viruses (AAVs) display a highly conserved NGR motif on the capsid surface. Earlier studies have established this tripeptide motif as being essential for integrin-mediated uptake of recombinant AAV serotype 2 (AAV2) in cultured cells. However, functional attributes of this putative integrin recognition motif in other recombinant AAV serotypes displaying systemic transduction in vivo remain...

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Identifiers

PMID: 25404742
DOI: 10.1074/jbc.M114.608281
PMCID: PMC4340397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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