Article
VAPSE-based analysis: a two-phased candidate gene approach for elucidating genetic predisposition to complex disorders.
Mutation research - 1 Jun 2001
Weinshenker B G, Sommer S
Abstract excerpt
The extraordinary success of linkage analysis in diseases with Mendelian inheritance has not extended readily to the genetics of common complex diseases. VAPSE-based analysis is a type of candidate gene approach that represents an alternative strategy by which genetic mechanisms can be defined despite the presence of substantial genetic heterogeneity. Recent advances in mutation screening and statistical...
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