Article
The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.
Clinical advances in hematology & oncology : H&O - 1 Oct 2011
Sundararajan Srinath, Ahmed Aisha, Goodman Oscar B
Abstract excerpt
The breast cancer susceptibility genes 1 (BRCA1) and 2 (BRCA2) are cellular proteins involved in DNA repair. They are normally expressed in the breast, ovaries, prostate, and other tissues. Their germline mutation is the cause of hereditary breast-ovarian cancer syndromes. BRCA mutation carriers are also susceptible to other cancers, notably prostate cancer. In this article, we review the role of BRCA genes in...
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