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Article

c-Myc-mediated regulation of telomerase activity is disabled in immortalized cells.

The Journal of biological chemistry - 10 Aug 2001

Drissi R, Zindy F, Roussel M F, Cleveland J L

Abstract excerpt

Myc overexpression is a hallmark of human cancer and promotes transformation by facilitating immortalization. This function has been linked to the ability of c-Myc to induce the expression of the catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), as ectopic expression of TERT immortalizes some primary human cell types. c-Myc up-regulates telomerase activity in primary mouse embryonic...

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Identifiers

PMID: 11402027
DOI: 10.1074/jbc.M101899200

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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