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Article

Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus.

PLoS pathogens - 1 Oct 2011

Tran-Winkler Hien J, Love John F, Gryllos Ioannis, Wessels Michael R

Abstract excerpt

The CsrRS (or CovRS) two component system controls expression of up to 15% of the genome of group A Streptococcus (GAS). While some studies have suggested that the sensor histidine kinase CsrS responds to membrane perturbations as a result of various environmental stresses, other data have implicated the human antimicrobial peptide LL-37 and extracellular Mg(2+) as specific signals. We now report that Mg(2+) and...

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Source

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Identifiers

PMID: 22046138
DOI: 10.1371/journal.ppat.1002361
PMCID: PMC3203184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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