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Article

Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells.

Nucleic acids research - 1 Jan 2006

Mechold Undine, Ogryzko Vasily, Ngo Saravuth, Danchin Antoine

Abstract excerpt

We identified Oligoribonuclease (Orn), an essential Escherichia coli protein and the only exonuclease degrading small ribonucleotides (5mer to 2mer) and its human homologue, small fragment nuclease (Sfn), in a screen for proteins that are potentially regulated by 3'-phosphoadenosine 5'-phosphate (pAp). We show that both enzymes are sensitive to micromolar amounts of pAp in vitro. We also demonstrate that Orn can...

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Identifiers

PMID: 16682444
DOI: 10.1093/nar/gkl247
PMCID: PMC1458514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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