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Article

Protein kinase D is sufficient to suppress EGF-induced c-Jun Ser 63 phosphorylation.

Biochemical and biophysical research communications - 30 Mar 2001

Hurd C, Rozengurt E

Abstract excerpt

Phosphorylation of c-Jun at Ser 63/73 by the c-Jun N-terminal kinase (JNK) potentiates the transactivation function of c-Jun. Protein kinase D (PKD), a downstream effector of protein kinase C (PKC), has been implicated in the attenuation of epidermal growth factor (EGF)-induced activation of JNK. In order to determine whether activated PKD is sufficient to modulate the EGF-JNK-c-Jun pathway, we have developed a...

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Source

Identifiers

PMID: 11401472
DOI: 10.1006/bbrc.2001.4591

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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