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Article

Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene.

Genetics and molecular research : GMR - 28 Mar 2007

Rincón G, Young A E, Bannasch D L, Medrano J F

Abstract excerpt

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized...

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Source

Identifiers

PMID: 17469064

Genes

SOCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17469064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene.PMID 17469064Read ↗

Lack of Socs2 expression causes the high-growth phenotype in mice.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in the entire coding region of the SOCS2 gene with milk traits in Sahiwal cattle.Semantic proximity Read ↗

A single nucleotide polymorphism in suppressor of cytokine signalling-2 is associated with growth and feed conversion efficiency in pigs.Semantic proximity Read ↗

A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.Semantic proximity Read ↗

Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness.Semantic proximity Read ↗

Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in VertebratesSemantic proximity Read ↗

Mutation of SOCS2 induces structural and functional changes in mammary development.Semantic proximity Read ↗

Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone SignalingSemantic proximity Read ↗

Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.Semantic proximity Read ↗

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