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Article

Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene.

Genetics and molecular research : GMR - 28 Mar 2007

Rincón G, Young A E, Bannasch D L, Medrano J F

Abstract excerpt

Suppressor of cytokine signaling 2 (SOCS2) is a negative regulator of growth hormone signaling. The deletion of SOCS2 in mice results in a 30-50% increase in post-natal growth. In an effort to identify polymorphisms in the SOCS2 gene that may be associated with body size in dogs, we characterized the canine SOCS2 gene and analyzed its genetic diversity among small and large dog breeds. The study was carried out...

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Source

Identifiers

PMID: 17469064

Genes

SOCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of variation in the canine suppressor of cytokine signaling-2 (SOCS2) gene.PMID 17469064Read ↗

Lack of Socs2 expression causes the high-growth phenotype in mice.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in the entire coding region of the SOCS2 gene with milk traits in Sahiwal cattle.Semantic proximity Read ↗

A single nucleotide polymorphism in suppressor of cytokine signalling-2 is associated with growth and feed conversion efficiency in pigs.Semantic proximity Read ↗

A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.Semantic proximity Read ↗

Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness.Semantic proximity Read ↗

Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in VertebratesSemantic proximity Read ↗

Mutation of SOCS2 induces structural and functional changes in mammary development.Semantic proximity Read ↗

Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone SignalingSemantic proximity Read ↗

Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.Semantic proximity Read ↗

A single IGF1 allele is a major determinant of small size in dogs.Semantic proximity Read ↗

Nucleotide sequence of canine Smad3.Semantic proximity Read ↗

Identification and characterization of a SSCP marker in the canine signal sequence receptor beta subunit gene.Semantic proximity Read ↗

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