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Article

Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer.

International journal of cancer - 20 Jul 2001

Hernando E, Orlow I, Liberal V, Nohales G, Benezra R, Cordon-Cardo C

Abstract excerpt

During the metaphase-anaphase transition, the spindle checkpoint prevents segregation of chromosomes if the spindle assembly is perturbed. Critical components of this checkpoint are the MAD and BUB families of proteins, which prevent the proteolysis of Pds1 and B cyclins, producing mitotic arrest. In the present study, we first intended to resolve the role of the hsMAD2 gene in human cancer by determining the...

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Source

Identifiers

PMID: 11400114
DOI: 10.1002/1097-0215(20010720)95:4<223::aid-ijc1038>3.0.co;2-l

Genes

GAA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer.PMID 11400114Read ↗

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