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Article

Natural Occurring Polymorphisms in HIV-1 Integrase and RNase H Regulate Viral Release and Autoprocessing.

Journal of virology - 9 Nov 2021

Imamichi Tomozumi, Bernbaum John G, Laverdure Sylvain, Yang Jun, Chen Qian, Highbarger Helene, Hao Ming, Sui Hongyan, Dewar Robin, Chang Weizhong, Lane H Clifford

Abstract excerpt

Recently, a genome-wide association study using plasma HIV RNA from antiretroviral therapy-naive patients reported that 14 naturally occurring nonsynonymous single-nucleotide polymorphisms (SNPs) in HIV derived from antiretrovirus drug-naive patients were associated with virus load (VL). Those SNPs were detected in reverse transcriptase, RNase H, integrase, envelope, and Nef. However, the impact of each mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34523971
DOI: 10.1128/JVI.01323-21
PMCID: PMC8577372

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