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Noncytotoxic Lytic Granule–Mediated CD8 <sup>+</sup> T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

10 Oct 2008

Abstract excerpt

Reactivation of herpes simplex virus type 1 (HSV-1) from neuronal latency is a common and potentially devastating cause of disease worldwide. CD8+ T cells can completely inhibit HSV reactivation in mice, with interferon-gamma affording a portion of this protection. We found that CD8+ T cell lytic granules are also required for the maintenance of neuronal latency both in vivo and in ex vivo ganglia cultures and...

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PMID: 18845757
DOI: 10.1126/science.1164164

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