Article
Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum.
Bioscience, biotechnology, and biochemistry - 1 Nov 1992
Iriye R, Furukawa K, Nishida R, Kim C, Fukami H
Abstract excerpt
A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD50 = 95 micrograms/ml against UV-induced mutagenic E. coli WP2 B/r Trp-. Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300...
Topics
- Antimutagenic Agents
- Biotechnology
- Caffeic Acids
- Escherichia coli
- Isomerism
- Mutation
- Plants, Medicinal