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Article

Alzheimer's disease. Molecular consequences of presenilin-1 mutation.

Nature - 7 Jun 2001

Gandy S, Naslund J, Nordstedt C

Abstract excerpt

Alzheimer's disease is characterized by accumulation in the brain of a family of insoluble amyloid peptides (Abeta peptides), which are produced as a result of the normal processing of beta-amyloid precursor protein (beta-APP). Russo et al. claim that a truncated Abeta peptide that lacks the first ten amino acids accumulates in the brains of patients carrying a mutant form of pre-senilin 1 (PS1), a protein that...

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Source

Identifiers

PMID: 11395757
DOI: 10.1038/35079682

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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