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Article

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

The Journal of biological chemistry - 13 May 2005

Nakaya Yoshifumi, Yamane Takuya, Shiraishi Hirohisa, Wang Hua-Qin, Matsubara Etsuro, Sato Toru, Dolios Georgia, Wang Rong, De Strooper Bart, Shoji Mikio, Komano Hiroto, Yanagisawa Katsuhiko, Ihara Yasuo, Fraser Paul, St George-Hyslop Peter, Nishimura Masaki

Abstract excerpt

Familial Alzheimer disease-causing mutations in the presenilins increase production of longer pathogenic amyloid beta-peptides (A beta(42/43)) by altering gamma-secretase activity. The mechanism underlying this effect remains unknown, although it has been proposed that heteromeric macromolecular complexes containing presenilins mediate gamma-secretase cleavage of the amyloid beta-precursor protein. Using a random...

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PMID: 15764596
DOI: 10.1074/jbc.M501130200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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