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Article

Hepatic expression of SV40 small-T antigen blocks the in vivo CD95-mediated apoptosis.

Biochemical and biophysical research communications - 8 Jun 2001

Gillet R, Cavard C, Grimber G, Briand P, Joulin V

Abstract excerpt

We have previously demonstrated that CD95-mediated apoptosis of hepatocytes is blocked in a murine model of hepatocarcinogenesis due to the expression of SV40 early sequences encoding the large-T and small-t antigens. In this study, we set out to pinpoint the sequences involved in this apoptosis-resistant phenotype, and tested several mutants of the SV40 early region for their ability to confer protection against...

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Identifiers

PMID: 11394888
DOI: 10.1006/bbrc.2001.4988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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