Article
Mutation rates in the dihydrofolate reductase gene of Plasmodium falciparum.
Parasitology - 1 May 2001
Paget-McNicol S, Saul A
Abstract excerpt
A new method has been established to define the limits on a spontaneous mutation rate for a gene in Plasmodium falciparum. The method combines mathematical modelling and large-scale in vitro culturing and calculates the difference in mutant frequencies at 2 separate time-points. We measured the mutation rate at 2 positions in the dihydrofolate reductase (DHFR) gene of 3D7, a pyrimethamine-sensitive line of P....
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