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Article

Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner.

Hepatology (Baltimore, Md.) - 1 Jun 2001

Podevin P, Sabile A, Gajardo R, Delhem N, Abadie A, Lozach P Y, Beretta L, Bréchot C

Abstract excerpt

The impact of hepatitis C virus NS5A protein mutations on interferon alfa (IFN-alpha) signaling pathway, cell proliferation, and viability is an important issue that is still under debate. We have therefore combined transient and stable expression in a human hepatocytic cell line (Huh7) of 3 full-length NS5A sequences, isolated from patients with or without response to IFN-alpha therapy. Expression of all 3...

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Identifiers

PMID: 11391540
DOI: 10.1053/jhep.2001.24749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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